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These inadequacies emphasize the need for a more comprehensive, unifying mechanism to elucidate the complex relationship between CVDs and cognitive impairment at cellular and molecular levels, and underscore the urgency of further research into mitochondrias role in this comorbidity

B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from multiple sclerosis, pernicious anaemia, Crohns or celiac disease